أداة سريرية
منصة تقييم مخاطر الثلث الأول من الحمل
منصة شاملة لتقييم مخاطر الثلث الأول من الحمل. تدمج علامات الموجات فوق الصوتية وتاريخ الأم والكيمياء الحيوية باستخدام نهج المخاطر المتنافسة.
الغرض السريري
To provide advanced patient-specific risk estimation for chromosomal anomalies (Trisomy 21, 18, 13), preeclampsia, and fetal growth restriction in the first trimester (11-13+6 weeks).
المدخلات
- Maternal characteristics and medical history
- Ultrasound markers (NT, CRL, Nasal Bone, Tricuspid Regurgitation, Ductus Venosus)
- Biomarkers (PAPP-A, free β-hCG, PlGF)
- Biophysical parameters (MAP, Uterine Artery PI)
المصادر والمعايير
Fetal Medicine Foundation (FMF) algorithms and multi-center validation studies.
القيود
Risk calculation is a screening process, not a definitive diagnosis. High-risk results should be followed by diagnostic testing (e.g., CVS or Amniocentesis) and expert clinical counseling. This tool is for educational and supportive purposes and does not replace clinical judgment.
الأسئلة الشائعة
When is the optimal time for the first-trimester scan?
The optimal time is between 11 weeks and 13 weeks + 6 days of gestation, corresponding to a crown-rump length (CRL) of 45 to 84 mm.
How does the competing risks model differ from traditional screening?
A competing risks model considers that the occurrence of one event (e.g., delivery at a given gestation) precludes the occurrence of another (e.g., developing preeclampsia at a later gestation). This provides a more accurate, personalized risk trajectory.
المراجع
- Nicolaides KH. Turning the pyramid of prenatal care. Fetal Diagn Ther. 2011.
- Wright D, et al. A competing risks model in early screening for preeclampsia. Fetal Diagn Ther. 2012.
- O'Gorman N, et al. Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. Am J Obstet Gynecol. 2016.